The maneuvers, which state TV said took place over the weekend, came as Syria said it was still negotiating with the Arab League over the bloc's request to send observers into the country.
Syria's military conducts war game every year but these maneuvers were of a higher-level, combining missile tests, the air force and ground troops.
State TV said the exercise was meant to test "the capabilities and the readiness of missile systems to respond to any possible aggression."
The drill showed Syrian missiles and troops were "ready to defend the nation and deter anyone who dares to endanger its security" and that the missiles hit their test targets with precision, the TV said.
In October, Assad warned the Middle East "will burn" if the West intervenes in Syria and threatened to turn the region into "tens of Afghanistans."
Syria is known to have surface-to-surface missiles such as Scuds, capable of hitting deep inside its archenemy Israel.
Source: AP; Photo: SANA